Scientists found that men who took the drugs suffered damage to the DNA of their sperm cells which could hinder them fathering children. The research, carried out by Cornell Medical Center in New York, found that although the sperm appeared healthy, closer inspection showed the amount of DNA fragmentation more than doubled in men on the medication. The findings, published in New Scientist, once again throw the spotlight on the most commonly prescribed anti-depressants known as selective serotonin re-uptake inhibitors SSRIs that have also been linked to suicide in the past. There were more than 16 million prescriptions for SSRIs in , although there is no record on how many people used them or how many of the prescriptions went to men. In the latest study, a team led by Peter Schlegal and Cigdem Tanrikut, gave 35 healthy men doses of paroxetine, a popular SSRI sold as Seroxat and Paxil, over five weeks and examined their sperm. Superficially, the men's sperm seemed healthy — the amounts of sperm and semen, and the shape and motility of sperm, were all normal.
Depression Medications May Reduce Male Fertility
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Correspondence Address : Dr. This study was conducted to clarify the toxic effects of sertraline SRT on the reproductive system of male rats and to elucidate the underlying mechanisms. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted. Serum testosterone, follicle-stimulating hormone FSH , and luteinizing hormone LH levels were measured to determine the effects of SRT on the spermatogenesis process. Decreased sperm count was accompanied by a significant increase in abnormal sperm morphology, DNA damage, and degeneration in cellular-tubular structures. In conclusion, SRT induced testicular toxicity in a dose-dependent manner and OS is suggested as a crucial mechanism.
Effects of selective serotonin reuptake inhibitors on sperm and male fertility
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Skip to search form Skip to main content. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. View PDF.